MNDPDP ENHANCEMENT IN RABBIT LIVER AFTER INTRAVENOUS BOLUS INJECTION AND SLOW INFUSION

Purpose: To investigate the MR-enhancing effect of mangafodipir trisod ium (MnDPDP, Teslascan) in the rabbit liver in relation to dose, mode of administration and imaging window. Material and Methods: MnDPDP was administered to 18 rabbits at a dose of 10 mu mol/kg or 20 mu mol/kg, as a bolus injection or infusion. MR imaging of the liver was perform ed at different time intervals. Results: Peak liver enhancement was ty pically observed 10-30 min after administration and the enhancement de clined with a half-time of about 5 h. This pattern was observed in all sequences (SE 400/15, FLASH, and SE 132/10), with both doses and with both rates of administration. The peak enhancement was greater, thoug h not significantly so after 20 mu mol/kg than after 10 mu mol/kg. A h igher relative peak signal was observed with SE 132/10 than with FLASH or SE 400/15. Conclusion: A good liver imaging result was obtained af ter a dose of 10 mu mol/kg, either bolus or infusion, 10-30 min post-c ontrast with heavily T1-weighted sequences.