Regulation of PTEN transcription by p53

Citation
V. Stambolic et al., Regulation of PTEN transcription by p53, MOL CELL, 8(2), 2001, pp. 317-325
Citations number
30
Categorie Soggetti
Cell & Developmental Biology
Journal title
MOLECULAR CELL
ISSN journal
10972765 → ACNP
Volume
8
Issue
2
Year of publication
2001
Pages
317 - 325
Database
ISI
SICI code
1097-2765(200108)8:2<317:ROPTBP>2.0.ZU;2-L
Abstract
PTEN tumor suppressor is frequently mutated in human cancers and is a negat ive regulator of P13'K/PKB/Akt-dependent cellular survival. Investigation o f the human genomic PTEN locus revealed a p53 binding element directly upst ream of the PTEN gene. Deletion and mutation analyses showed that this elem ent is necessary for inducible transactivation of PTEN by p53. A p53-indepe ndent element controlling constitutive expression of PTEN was also identifi ed. In contrast to p53 mutant cell lines, induction of p53 in primary and t umor cell lines with wild-type p53 increased PTEN mRNA levels. PTEN was req uired for p53-mediated apoptosis in immortalized mouse embryonic fibroblast s. Our results reveal a unique role for p53 in regulation of cellular survi val and an interesting connection in tumor suppressor signaling.