The human nose is often considered something of a luxury, but in the rest o
f the animal world, from bacteria to mammals, detecting chemicals in the en
vironment has been critical to the successful organism. An indication of th
e importance of olfactory systems is the significant proportion-as much as
4%-of the genomes of many higher eukaryotes that is devoted to encoding the
proteins of smell. Growing interest in the detection of diverse compounds
at single-molecule levels has made the olfactory system an important system
for biological modelling.