PTPRC (CD45) is not associated with the development of multiple sclerosis in US patients

Authors
Barcellos, LF Caillier, S Dragone, L Elder, M Vittinghoff, E Bucher, P Lincoln, RR Pericak-Vance, M Haines, JL Weiss, A Hauser, SL Oksenberg, JR
Citation
Lf. Barcellos et al., PTPRC (CD45) is not associated with the development of multiple sclerosis in US patients, NAT GENET, 29(1), 2001, pp. 23-24
Citations number
9
Categorie Soggetti
Molecular Biology & Genetics
Journal title
NATURE GENETICS
ISSN journal
10614036 → ACNP
Volume
29
Issue
1
Year of publication
2001
Pages
23 - 24
Database
ISI
SICI code
1061-4036(200109)29:1<23:P(INAW>2.0.ZU;2-3
Abstract
A C-->G nucleotide transition in exon 4 of PTPRC (encoding protein-tyrosine phosphatase receptor-type C, also known as CD45) was recently reported to be genetically associated with the development of multiple sclerosis (MS)(1 ). We performed an extensive evaluation of this polymorphism using large fa mily-based and case-control comparisons. Overall, we observed no evidence o f genetic association between the PTPRC polymorphism and MS susceptibility or disease course.