New insights into the pathogenesis of systemic lupus erythematosus (SLE): the role of apoptosis

Authors
Bijl, M Limburg, PC Kallenberg, CGM
Citation
M. Bijl et al., New insights into the pathogenesis of systemic lupus erythematosus (SLE): the role of apoptosis, NETH J MED, 59(2), 2001, pp. 66-75
Citations number
76
Categorie Soggetti
General & Internal Medicine
Journal title
NETHERLANDS JOURNAL OF MEDICINE
ISSN journal
03002977 → ACNP
Volume
59
Issue
2
Year of publication
2001
Pages
66 - 75
Database
ISI
SICI code
0300-2977(200108)59:2<66:NIITPO>2.0.ZU;2-H
Abstract
In recent years disturbances in the process of apoptosis and the clearance of apoptotic cells have been put forward as fundamental in the development of autoimmunity. In this review we will discuss the data which supply evide nce for this theory. We will focus on SLE as the prototype of autoimmune di sease and will review both animal studies and clinical studies in SLE patie nts. (C) 2001 Published by Elsevier Science B.V.