Twenty-nine patients with secondary progressive MS underwent monthly assess
ment with Expanded Disability Status Scale (EDSS), MS Functional Composite
(MSFC), MS Quality of Life-54, and cranial MRI over 6 months. Overall quali
ty of life (OQOL) correlated highly with emotional well-being, the mental h
ealth composite, health distress, and the physical health composite. In con
trast, there was no statistical evidence of consistent correlation between
OQOL and EDSS, MSFC, or MR outcome measures.