Cooling garment treatment in MS: Clinical improvement and decrease in leukocyte NO production

Authors
Beenakker, EAC Oparina, TI Hartgring, A Teelken, A Arutjunyan, AV De Keyser, J
Citation
Eac. Beenakker et al., Cooling garment treatment in MS: Clinical improvement and decrease in leukocyte NO production, NEUROLOGY, 57(5), 2001, pp. 892-894
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
57
Issue
5
Year of publication
2001
Pages
892 - 894
Database
ISI
SICI code
0028-3878(20010911)57:5<892:CGTIMC>2.0.ZU;2-P
Abstract
Ten heat-sensitive patients with MS were randomly allocated in a cross-over study to wear a cooling garment for 60 minutes at 7 degreesC (active cooli ng) and 26 degreesC (sham cooling). In contrast to sham cooling, active coo ling improved fatigue and postural stability with eyes closed and muscle st rength. There was no decrease in tympanic temperature, but active cooling w as associated with a 41% decrease in mean leukocyte nitric oxide (NO) produ ction (p = 0.004). This effect on NO could be relevant because it blocks co nduction in demyelinated axons.