Objective assessment of progression in Huntington's disease: A 3-year follow-up study

Objective measures to assess progression of Huntington's disease (HD) are d esirable. The authors have previously found that patients with HD with high er Unified Huntington's Disease Rating Scale (UHDRS) motor scores exhibited higher variability of isometric grip forces while grasping an object. Ther efore, the authors assessed grip force variability during this task in 10 H D patients with a 3-year follow-up. Grip force variability increased in all patients at the follow-up. Thus, grip force variability during grasping mi ght be an objective and quantitative measure to assess motor deficits assoc iated with the progression of HD.