Objective measures to assess progression of Huntington's disease (HD) are d
esirable. The authors have previously found that patients with HD with high
er Unified Huntington's Disease Rating Scale (UHDRS) motor scores exhibited
higher variability of isometric grip forces while grasping an object. Ther
efore, the authors assessed grip force variability during this task in 10 H
D patients with a 3-year follow-up. Grip force variability increased in all
patients at the follow-up. Thus, grip force variability during grasping mi
ght be an objective and quantitative measure to assess motor deficits assoc
iated with the progression of HD.