Inhibition of the glutamate transporter by L-trans-PDC in the nucleus accumbens prevents the locomotor response to amphetamine

Authors
David, HN Thevenoux, A Abraini, JH
Citation
Hn. David et al., Inhibition of the glutamate transporter by L-trans-PDC in the nucleus accumbens prevents the locomotor response to amphetamine, NEUROPHARM, 41(3), 2001, pp. 409-411
Citations number
10
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROPHARMACOLOGY
ISSN journal
00283908 → ACNP
Volume
41
Issue
3
Year of publication
2001
Pages
409 - 411
Database
ISI
SICI code
0028-3908(200109)41:3<409:IOTGTB>2.0.ZU;2-J
Abstract
Infusion in the nucleus accumbens of the glutamate uptake inhibitor L-trans -PDC prevented the amphetamine-induced locomotor response. Since L-trans-PD C has been shown to block the amphetan-tine-induced increase in glutarnate but not in DA release, our result indicates that the glutamate transporter is an obligatory target for the activating properties of amphetamine. (C) 2 001 Elsevier Science Ltd. All rights reserved.