Association study between novel promoter variants at the 5-HT2C receptor gene and human patients with bipolar affective disorder

Two recently described adjacent DNA polymorphisms [(GT)12-18 and (CT)4-5] i n the W-regulatory region of 5-HT2C receptor gene were analysed in a sample of 88 bipolar patients and 162 controls, all of Spanish origin. Statistica l analyses revealed no overall allele or genotype associations with the dis ease. A haplotype analyses between the (GT)12-18/(CT)4-5 motif and a Cys23S er variant of the 5-HT2C gene (which had previously been genotyped in the s ame sample) showed similar distributions between cases and controls. Only a slight increase of s-Ser23 haplotype was found in the subgroup of bipolar women with family history of psychiatric illness (OR = 1.24 [95%Cl: 1.12-1. 38]). (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.