PROGNOSTIC FACTORS IN ENDOMETRIAL CARCINOMA - RISK GROUPS AND ADJUVANT RADIOTHERAPY

Prognostic factors for disease-free survival in patients with endometr ial carcinoma have been retrospectively assessed in 611 cases diagnose d, treated and followed at our institution between 1971 and 1990. Age, symptoms, comorbidity, FIGO clinical stage, and hysterometry, as well as size and location of the tumor, histologic type, FIGO grade, myome trial invasion, lympho-vascular invasion, and final surgical stage hav e all been evaluated by univariate and multivariate methods. A mathema tical predictive model has been applied to define risk groups, and the applied adjuvant treatments have been evaluated according to these gr oups. One hundred and thirtyone patients were not treated primarily wi th surgey, and the actuarial 5 and 10-year diesase-free survival was 5 1.6% and 34.7% respectively. Only clinical stage (FIGO 1971) and modal ity of radiotherapy were signifcant prognostic factors. For the 480 pa tients treated primarily by surgery, independent prognostic factors fo r 5 and 10-year disease-free survival in multivariate analysis were ex trauterine spread, absence of diagnostic comorbidity, FIGO grades 2-3, lympho-vascular invasion, age > 65 years and cervical extension. Five and 10-year disease-free survival was 81.5% and 73.4% respectively. T hree risk groups were obtained, whose survival was not affected by the adjuvant treatments applied.