Purpose: To estimate the minimum stimulus energy required to stimulate the
corneal nerves, using a thermally cooling stimulus.
Methods: The localised temperature change produced in the pre-corneal tear
film by the air-pulse stimulus of the Non-Contact Corneal Aesthesiometer (N
CCA) was analysed using a thermal imaging camera. Assuming that the cornea
behaves as a near perfect black-body, the threshold for energy loss was cal
culated by combining Stefan-Boltzmann's law and Kirchoff's law for imperfec
tions in black-body radiation, taking into account the likely thermal condu
ctivity of the human cornea.
Results:The average normal subject has a threshold for detecting a cooling
effect when the local corneal tear film surface temperature drops from a me
an of 33.2-32.9 degreesC (i.e. 0.3 degreesC), over a 1 mm diameter circular
area (0.785 mm(2)), and a stimulus time duration of 0.9 s. This gives rise
to a sensation threshold for perceiving a loss of heat energy of 7.0 ergs,
or 7.0 X 10(-7) joules.
Conclusion: The cornea possesses stimulus specific receptors, which have an
exquisite sensitivity to a rapid, thermally cooling stimulus. (C) 2001 The
College of Optometrists. Published by Elsevier Science Ltd. All rights res
erved.