Solid-phase synthesis of 1,7-disubstituted-1,3,5-triazepane-2,4-diones

Authors
Yu, YP Ostresh, JM Houghten, RA
Citation
Yp. Yu et al., Solid-phase synthesis of 1,7-disubstituted-1,3,5-triazepane-2,4-diones, ORG LETT, 3(18), 2001, pp. 2797-2799
Citations number
20
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
18
Year of publication
2001
Pages
2797 - 2799
Database
ISI
SICI code
1523-7060(20010906)3:18<2797:SSO1>2.0.ZU;2-L
Abstract
The solid-phase synthesis of 1,7-disubstituted-1,3,5-triazepane-2,4-diones from resin-bound amino acids is described. The exhaustive reduction of soli d-support bound amides with borane afforded the requisite secondary amines, which following treatment with phenyl isocyanatoformate and cleavage, prov ided the corresponding triazepane-2,4-diones.