A synthetic strategy for the cyclodepsipeptide core of the antitumor antibiotic verucopeptin

Authors
Hale, KJ Lazarides, L Cai, JQ
Citation
Kj. Hale et al., A synthetic strategy for the cyclodepsipeptide core of the antitumor antibiotic verucopeptin, ORG LETT, 3(18), 2001, pp. 2927-2930
Citations number
32
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
18
Year of publication
2001
Pages
2927 - 2930
Database
ISI
SICI code
1523-7060(20010906)3:18<2927:ASSFTC>2.0.ZU;2-L
Abstract
[GRAPHICS] An efficient [2 + 2 + 2]-fragment condensation strategy is described for ob taining the cyclodepsipeptide core of verucopeptin. The 19-membered macrocy cle was established through a Carpino HATU mediated macrolactamization, whi ch proceeded in good yield under high-dilution conditions.