We designed this project to determine community pharmacists' opinions regar
ding the challenges and motivations of their recent participation in a phar
macy practice-based research study. At the conclusion of a randomized, mult
icenter study, 87 community pharmacist-investigators were sent a questionna
ire that explored four areas: motivating factors to participate, barriers t
o participation, communication tools used by study coordinators, and design
issues for future studies. Fifty-eight (67%) completed questionnaires were
returned. Key factors motivating participation in the study were desire to
improve the profession and opportunity to learn. Time was the greatest bar
rier to participation. Pharmacy practice-based research has two distinct ad
vantages. First, it translates clinical knowledge into direct application i
n the community. Second, it provides needed data to demonstrate the value o
f enhanced pharmacy practice. Thorough understanding of pharmacists' opinio
ns is necessary to optimize the design of future studies.