The effects of oral selegiline hydrochloride on learning and training in the dog: A psychobiological interpretation

I, Twenty two healthy, non-problem dogs were assessed for their acquisition of three different learning tasks on consecutive days and on the extinctio n of the response in the third. In Task 1, dogs were trained to walk in a c ircle on command, In Task 2, dogs were trained to retreat and sit on a mat. In Task 3, dogs were assessed for the acquisition and extinction of an ope rant response (pawing a panel). 2. Dogs were orally administered a placebo or selegiline hydrochloride at a dose of 0.5mg/kg for a period of three weeks prior to testing and during t he test period. 3. Dog's treated with selegiline tended to perform better at tasks which we re clearly lured with a motivationally significant cue, performing a first correct response sooner and requiring fewer reinforcements to reach the suc cess criterion. They were also significantly more likely to walk over a nov el object placed on the floor of the test arena. In the absence of a signif icant lure, the selegiline treated dogs took significantly longer to reach the required performance criterion for the operant task. These dogs also ex tinguished their response more rapidly than the control group 4. In the third task, selegiline treated dogs were significantly less likel y to look away and throughout all tasks these dogs tended to be less distra cted than the placebo group. 5. These findings and other reports associated with the effects of selegili ne on learning may be explained by reference to the effects of selegiline o n dopaminergic structures associated with positive incentive motivation.