Background. Peripheral zone (PZ) and transition zone (TZ) cancers of the pr
ostate remain confined to their zone of origin under 4 cc volume, with prog
ressive molding to TZ boundary. In PZ cancer, growth in perineural spaces o
ver 4 cc volume directs cancer toward the base, around subcapsular nerve tr
unks, and often transcapsular. This tendency to stereotyped patterns of can
cer spread in the prostate is investigated systematically here for the firs
t time.
Methods. Cancers in 571 radical prostatectomy specimens were sorted by zone
of origin and tumor volume. A traced map of each cancer at 3 mm transverse
intervals was assessed for location, contour, selected linear measures and
the "transverse (largest) reference plane".
Results. Spread along prostate capsule characterized all but the smallest P
Z cancers and was most extensive transversely, By 4 cc volume, most PZ canc
ers' transverse reference plane filled one side of PZ Above 4 cc, bilateral
spread, TZ invasion, and nodularity progressively increased, but dominant
growth was toward the base along nerves to the superior pedicle; here capsu
le penetration was most common. TZ cancers arose mainly in anterior-mid TZ,
invading anterior fibromuscular stroma (ATM) while small. AFM was massivel
y invaded in many large tumors. Larger TZ cancers (>4 cc) invaded anterolat
eral PZ but seldom penetrated posterior PZ.
Conclusions. Patterns and extent of spread of carcinoma in the prostate are
stereotyped following a few principles regarding stromal interactions. Usi
ng these, sequential maps were presented of evolving prostate cancer contou
rs at consecutive increasing volumes. Prostate 49: 48-57,2001. (C) 2001 Wil
ey-Liss, Inc.