The present study examined the validity of Minnesota Multiphasic Personalit
y Inventory-2 (MMPI-2) typology for pregnant drug-dependent women. A 3-clus
ter solution based on 7 MMPI-2 clinical scales emerged as the best model an
d was replicated across split-half samples and different primary substance-
use diagnoses and treatment modalities. The 3 subtypes identified included
Type 1 (n = 40, 24%) with no clinical elevation, Type II (n = 72, 42%) with
elevated psychopathic deviate scale, and Type III (n = 58, 34%) with eleva
tions on all 7 scales. Analyses with interview and self-report measures sho
wed good concurrent validity. Type II had higher retention than Type I and
Type III across methadone and medication-free treatments, showing some pred
ictive validity. An a priori method for classifying new cases on the basis
of the proposed typology was developed and validated. Study findings suppor
t MMPI-2's use with pregnant drug-dependent women for assessment and possib
ly treatment planning.