DYSFUNCTION DIASTOLIC, LEFT-VENTRICULAR H YPERTROPHY AND MICROALBUMINURIA IN WILD TO MODERATE ESSENTIAL, HYPERTENSION

Introduction. It is known, that there is a high prevalence of left ven tricular diastolic disfunction, which precedes left ventricular hypert rophy in hypertensive people, but there is little published in literat ure about the relationship between these findings and the presence of microalbuminuria. Objective. In our study, we pretend to evaluate prev alence and eventual relation among microalbuminuria, diastolic disfunc tion and left ventricular hypertrophy, in young mild to moderate hyper tensive patients, non diabetic and without previous treatment. Materia l and methods. We studied prospectively 80 untreated hypertensive pati ents, with normal serum creatinine, and non diabetic (52.5% women and 47.5% men, mean age 41.4 +/- 9.6 years). We evaluated filling indexes by Doppler Ecocardiography: Ratio of early to late diastolic peak fill ing velocity and early filling deceleration time. Left ventricular hyp ertrophy was defined by Devereux's criteria. Microalbuminuria in twent y four hems was measured by radioimmunoassay in hypertensive patients (microalbuminuria: 30-300 mg/24 hours). Results. Microalbuminuria ocur red in 23.7%, left ventricular hypertrophy 40%, and diastolic disfunct ion 48.8%, no significant correlation existed between the same. Only 2 9.5% had no cardiac or renal disease. Statistically significant differ ences were found in ratio of early to late diastolic peak filling velo city and microalbuminuria, between the two study populations, but mult iple regression analysis didn't prove such correlation. Ratio of early to late diastolic peak filling velocity was independently related to age and diastolic blood pressure. Conclusions. There is a high prevale nce of cardiac and/or renal disease in mild hypertensive patients, onl y 29.5% of these patients are free of disease. We don't find relation between lesions in these organs.