Reduced oxygenation and erythropoietin

Authors
Gassmann, M
Citation
M. Gassmann, Reduced oxygenation and erythropoietin, SCHW A TIER, 143(9), 2001, pp. 455-460
Citations number
30
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
SCHWEIZER ARCHIV FUR TIERHEILKUNDE
ISSN journal
00367281 → ACNP
Volume
143
Issue
9
Year of publication
2001
Pages
455 - 460
Database
ISI
SICI code
0036-7281(200109)143:9<455:ROAE>2.0.ZU;2-Y
Abstract
Reduced oxygenation activates specific expression of erythropoietin (EPO) a nd other hypoxia-regulated genes. The cellular response to hypoxia is media ted by the hypoxia-inducible factor-1 (HIF-1). Unregulated overexpression o f EPO results in a hematocrit value of about 80%; transgenic mice were show n to adapt to this polyglobulia.