Synthesis of chemical modified beta-cyclodextrin and its inclusion behavior in alcohol/water mixed solvents

The chemical modified beta -cyclodextrin(CD), which bears a fluorophore gro up - N,N-dimethylaminochalcone (DMAC), was synthesized. The self-inclusion behavior of this compound in aqueous solution and in alcohol/water mixed so lvents was investigated in detail, and compared with the inclusion system o f non-modified CD with free DMAC molecule. The results showed that a deep s elf-inclusion complex was formed for this compound in aqueous solution and had the ability to recognize different organic molecules by two fully diffe rent modes: "in-out" and "co-inclusion" mechanisms. The inclusion behavior of these systems in various ratio of alcohol/water mixture as solvents was investigated. The results indicated that the self-inclusion complex has a h igher stability in alcohol/water mixed solvents than that in the case of no n-modified CD. The chalcone group appended at beta -CD enabled the host as a sensitive probe to study the inclusion behavior of CD.