A convenient synthesis of 4-trichloromethyl-pyrimidin-2-ylamine derivatives

Authors
Zanatta, N Pacholski, ID Faoro, D Bonacorso, HG Martins, MAP
Citation
N. Zanatta et al., A convenient synthesis of 4-trichloromethyl-pyrimidin-2-ylamine derivatives, SYN COMMUN, 31(18), 2001, pp. 2855-2863
Citations number
26
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
31
Issue
18
Year of publication
2001
Pages
2855 - 2863
Database
ISI
SICI code
0039-7911(2001)31:18<2855:ACSO4D>2.0.ZU;2-W
Abstract
A convenient method for the synthesis of a series of 4-trichloromethyl-pyri midin-2-ylamines from the reaction of 4-trichloromethyl-2-chloropyrimidine and ammonium hydroxide, primary- and secondary-amines, and guanidine hydroc hloride, is reported. This reactions was also extended to obtain 4-trichlor omethyl-2-alkoxy-pyrimidines.