Efficient fluorescein spirolactam and bis-spirolactam synthesis

Authors
Adamczyk, M Grote, J
Citation
M. Adamczyk et J. Grote, Efficient fluorescein spirolactam and bis-spirolactam synthesis, SYN COMMUN, 31(17), 2001, pp. 2681-2690
Citations number
19
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
31
Issue
17
Year of publication
2001
Pages
2681 - 2690
Database
ISI
SICI code
0039-7911(2001)31:17<2681:EFSABS>2.0.ZU;2-9
Abstract
Reaction of fluorescein methyl ester at ambient temperature with a variety of amines containing different functional groups afforded a family of spiro lactams, the structures of which were verified by MS, NMR, and x-ray crysta llography. Bis-spirolactams were prepared by subsequent reaction of an amin ospirolactam with another molecule of fluorescein methyl ester.