Mechanisms for oxidizing low-density lipoprotein - Insights from patterns of oxidation products in the artery wall and from mouse models of atherosclerosis

Authors
Gaut, JP Heinecke, JW
Citation
Jp. Gaut et Jw. Heinecke, Mechanisms for oxidizing low-density lipoprotein - Insights from patterns of oxidation products in the artery wall and from mouse models of atherosclerosis, TREND CARD, 11(3-4), 2001, pp. 103-112
Citations number
125
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
TRENDS IN CARDIOVASCULAR MEDICINE
ISSN journal
10501738 → ACNP
Volume
11
Issue
3-4
Year of publication
2001
Pages
103 - 112
Database
ISI
SICI code
1050-1738(200104/05)11:3-4<103:MFOLL->2.0.ZU;2-D
Abstract
The oxidation hypothesis proposes that oxidative modification of low densit y lipoprotein (LDL) plays a critical role in atherogenesis. This review cri tically evaluates the various mechanisms proposed for LDL oxidation, focusi ng on insights derived from chemical analysis of human artery wall and stud ies of genetically engineered mice. The implications of recent clinical tri als of vitamin E for the oxidation hypothesis are also briefly discussed. ( C) 2001, Elsevier Science Inc.