The influence of thrombophilic factors on the incidence of deep vein thrombosis and pregnancy complications

Pulmonary embolism and/or deep vein thrombosis are a major cause of materna l mortality. In a number of adverse pregnancy outcome including preeclampsi a, recurrent spontaneous abortion, restricted fetal growth and fetal death a role for thrombophilia (acquired and hereditable) has been postulated. Mo nitoring of acquired factors such as antiphospholipid-antibodies and heredi table factors (factor V Leiden, prothrombin mutation) may help predict the occurrence of pregnancy complications. Low molecular weight heparins (LMWH) , since their introduction well established during pregnancy, and the rate of adverse fetal outcomes are related to co-morbidity maternal conditions r ather than to the treatment itself. The use of LMWH is recommended for all moderate risk and high-risk pregnant patients.