Contact sensitivity reactions in the oral mucosa

Although the role of T cells in skill Contact sensitivity (CS) immune react ions, has been intensely studied, much less is known about the regulatory p roperties of T cells in the oral mucosa. Animal experiments have shown that hapten sensitization of the ectodermal till oral mucosa leads to antigen-s pecific hypersensitivity,it reactions in the skin. Furthermore, oral mucosa or skill hapten sensitization resulted in CS inflammatory, reactions in th e oral mucosa oil challenge. The oral mucosa CS responses were similar to t hose found skin with regard to cell phenotypes and cytokines. CS-like react ions were also found in the oral after exposure to an irritant detergent, s odium lauryl sulfate (SLS). The oral mucosa reacted at,,smaller SIS doses t han did skin. Ions and molecules released from dental restorative, material s (together with saliva and food and/or beverages) expose the gastrointesti nal mucosa;a continuously over long little periods. Front animal experiment s we have learned that mice given antigen by gastric feeding, subsequently antigen-sensitized oil skin, and finally elicited in the oral mucosa and in car skill, showed tolerance in skill but gave simultaneous CS inflammatory reactions in the oral mucosa. Moreover, exposure of colon mucosa to antige n produced CS reactions in oral mucosa after challenge. Are there CS reacti ons in the oral mucosa? Clinical and experimental studies indicate that the oral mucosa call function booth its induction all expression site of CIS. The GI tract may be all important modifier, of the CIS inflammatory reactio ns seen ill the oral mucosa.