E. Lechapt-zalcman et al., Association of primary pleural effusion lymphoma of T-cell origin and human herpesvirus 8 in a human immunodeficiency virus-seronegative man, ARCH PATH L, 125(9), 2001, pp. 1246-1248
Citations number
10
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
We describe a case of an 87-year-old human immunodeficiency virus (HIV)-neg
ative man who developed a primary pleural lymphoma without any identifiable
tumor mass associated with human herpesvirus 8 (HHV-8) infection. A large
T-cell lymphoma was diagnosed based on morphologic, immunophenotypic, and m
olecular findings. The HHV-8 DNA sequences were detected using specific pol
ymerase chain reaction amplification in the lymphomatous effusion. Study of
the patient's serum confirmed the HHV-8 infection. This case report displa
ys the characteristic features of HHV-8-related body cavity-based lymphoma/
primary effusion lymphoma previously reported in HIV-seronegative patients,
except that it is of T-cell origin. Whether th is case may be included or
not within the primary effusion lymphoma entity, the association of a pleur
al T-cell non-Hodgkin lymphoma with HHV-8 infection raises the question of
the possible occurrence of T cells as the target of malignant transformatio
n associated with HHV-8 infection.