Dietary D-psicose, a C-3 epimer of D-fructose, suppresses the activity of hepatic lipogenic enzymes in rats

D-Psicose (D-ribo-2-hexulose), a C-3 epimer Of D-fructose, is present in sm all quantities in commercial carbohydrate complexes or agricultural product s. Wistar male rats were fed experimental diets which consisted of 5% D-psi cose, Cellulose, D-fructose or D-glucose for 28 days. Abdominal adipose tis sue weight was significantly lower (P<0.05) in rats fed the D-psicose diet than in rats fed a D-fructose and D-glucose diets, even though the four die tary groups were offered the same amount throughout the experimental period . Fatty acid synthase and glucose 6-phosphate dehydrogenase activities in t he liver were significantly lower (P<0.05) in rats fed the D-psicose diet t han in rats fed the D-fructose and D-glucose diets. However, lipoprotein li pase activities in the heart, soleus muscle and perirenal adipose tissue we re the same. These results suggest that a supplement of D-psicose in the di et suppresses hepatic lipogenic enzyme activities. The lower abdominal fat accumulation in rats fed a D-psicose diet might result from lower lipogenes is in the liver.