NGC 4485 is a late-type galaxy moving through the very extended HI envelope
of its companion, NGC 4490. NGC 4485 is undetected in HI, CO and IRAS wave
bands, but a peak at all of these frequencies is seen displaced from the op
tical disk. HI data show a prominent bow-shock ahead of this displaced gas.
It is argued that almost the entire ISM, including molecular clouds, has b
een stripped from this galaxy by ram-pressure, and that it will emerge from
the encounter with very little star forming potential.