Autoaugmentation peritoneocystoplasty in a sheep model

Objective To report our experience with autoaugmentation peritoneocystoplas ty (AAPC) in a sheep model, and to compare the results with autoaugmentatio n gastrocystoplasty (AAGC) in a sheep model and in paediatric patients. Materials and methods Ten 6-month-old male lambs underwent bladder augmenta tion by detrusorotomy. A flap of parietal peritoneum, dissected from the an terior abdominal wall, was used to cover the bladder mucosa. The sheep were evaluated by urodynamics 6 months after surgery. Bladder compliance (bladd er volume/intravesical pressure) was calculated for the bladder capacity at leakage. The urodynamic results were compared with age-matched control she ep and with 12 sheep that had undergone AAGC: the results were assessed usi ng the Mann-Whitney U-test. Results In two of the 10 sheep, bladder volumes after AAPC increased by >10 0%, although for the group, the mean (range) bladder volume after augmentat ion, at 159 (42-261) mL was not significantly different from that before su rgery (mean 143 mL). Bladder volumes after AAPC were not significantly diff erent from those in the control sheep (mean 205 mL) but were significantly less than in the AAGC group (mean 317 mL: P < 0.05). Bladder compliance at leak capacity in the AAPC group (mean 5.4 mL/cmH(2)O) was also not signific antly different from the controls (mean 9.1 mL/cmH(2)O), but was lower than the in the AAGC animals (median 14.6 mL/cmH(2)O: P < 0.05). Conclusions AAPC in a sheep model does not result in a reliable increase in bladder volume or compliance. The volume and compliance are inferior to th ose found in bladders augmented by AAGC.