CHARACTERIZATION OF QUINOLINE DERIVATIVES .1. ETHYL-1-PIPERAZINYL)[1]BENZOXEPINO[4,5-C]QUINOLINE 0.13-HYDRATE

The title compound, C22H23N3O.0.13H(2)O, is a novel potent and selecti ve serotonin 5-HT3 receptor antagonist. Three independent molecules co nstitute the asymmetric unit. While two of these molecules show only s mall differences in their metric and conformational parameters, the th ird differs from the other two, mainly as a result of the conformation of the oxepine ring. The conformations of the seven-membered ring det ermine quite different orientations of the oxepine-fused benzene ring, whose role is important in the exploitation of biological activity.