Enhancement in fecal excretion of dioxin isomer in mice by several dietaryfibers

The effect of increased nutrients (protein, lipid. vitamins and minerals) o n dioxin-induced toxic manifestations such as immune suppression, hepatic h ypertrophy, splenic atrophy and enzyme induction was investigated in mice a fter oral administration of 1,2,3,4,7,8-HxCDD (HxCDD) as one of a represent ative compound of dioxin isomers. Consequently, it appeared that increased minerals and vitamins in the diet prevented immune suppression by HxCDD. In addition, to clarify the additive effect of nutrients and the ability to h asten the excretion of dioxins by dietary fiber, the adsorbing of dioxins b y 16 dietary fibers was investigated by in vitro experiment. Among 16 dieta ry fibers, locust bean gum, pectin, alginic acid, guar gum, chitin and cell ulose were effective in binding dioxin isomers. These dietary fibers also e nhanced the fecal excretion of HxCDD in mice. (C) 2001 Elsevier Science Ltd . All rights reserved.