This article reviews the literature on the application of methods for
the detection of growth factors, oncogene proteins, and tumor-suppress
or gene proteins in the blood of humans with cancer or who are at risk
for the development of cancer. The research summarized here suggests
that many of these biomarker assays can be used to distinguish between
diseased and nondiseased slates and in some instances may be able to
predict susceptibility for future disease. Thus, these biomarkers coul
d be valuable tools for monitoring at-risk populations for purposes of
disease prevention and control.