CORRELATIONS BETWEEN RESTING REGIONAL WALL-MOTION AND REGIONAL MYOCARDIAL BLOOD-FLOW (AT REST AND DURING EXERCISE) IN INFARCT-RELATED MYOCARDIUM - A STUDY WITH [N-13] AMMONIA POSITRON EMISSION TOMOGRAPHY
Y. Akutsu et al., CORRELATIONS BETWEEN RESTING REGIONAL WALL-MOTION AND REGIONAL MYOCARDIAL BLOOD-FLOW (AT REST AND DURING EXERCISE) IN INFARCT-RELATED MYOCARDIUM - A STUDY WITH [N-13] AMMONIA POSITRON EMISSION TOMOGRAPHY, Japanese Circulation Journal, 61(8), 1997, pp. 665-672
We evaluated quantitatively the correlations between resting wall moti
on and regional myocardial blood flow (RMBF; at rest and during exerci
se) in infarct-related myocardium. The study was performed in 28 subje
cts: 21 patients who had previously suffered myocardial infarction of
the anteroseptal wall, and 7 normal individuals. Positron emission tom
ography (PET) with [N-13]ammonia was performed at rest and during low-
grade exercise (bicycle ergometer fixed at 25 W for 6.5 min), and RMBF
was measured quantitatively from the radioactivity in myocardial tiss
ue and arterial blood. Resting regional wall motion was calculated usi
ng the centerline method on left ventriculographic finding, Resting re
gional wall motion was correlated with RMBF both at rest and during ex
ercise in the infarct areas (anterior walls: y=-2.74+4.25 X 10(-2)x, r
=0.43, at rest; and y=-2.48+3.04 X 10(-2)x, r=0.48, during exercise, p
<0.05; septal walls: y=-3.61+5.64 X 10(-2)x, r=0.62, at rest; and y=-3
.46+4.31 X 10(-2)x, r=0.62, during exercise, p<0.01). In each infarct-
related wall, the coefficient (the slope) during exercise was smaller
than that at rest (3.04 vs 4.25 and 4.31 vs 5.64 in each), and the inf
arct areas with preserved wall motion showed higher RMBF during exerci
se than those with reduced wall motion. Our results may show that wall
motion depends on viable but ischemic myocardium in infarct-related w
alls.