Effects of different continuous positive airway pressure devices and periodic hyperinflations on respiratory function

Objective: To compare the effect on respiratory function of different conti nuous positive airway pressure systems and periodic hyperinflations in pati ents with respiratory failure. Design: Prospective Setting: Hospital intensive care unit. Patients: Sixteen intubated patients (eight men and eight women, age 54 +/- 18 yrs, Pao(2)/Fio(2) 277 +/- 58 torr, positive end-expiratory pressure 6. 2 +/- 2.0 cm H2O). Interventions: We evaluated continuous flow positive airway pressure system s with high or low flow plus a reservoir bag equipped with spring-loaded me chanical or underwater seal positive end-expiratory pressure valve and a co ntinuous positive airway pressure by a Servo 300 C ventilator with or witho ut periodic hyperinflations (three assisted breaths per minute with constan t inspiratory pressure of 30 cm H2O over positive end-expiratory pressure). Measurements and Main Results: We measured the respiratory pattern, work of breathing, dyspnea sensation, end-expiratory lung volume, and gas exchange . We found the following: a) Work of breathing and gas exchange were compar able between continuous flow systems; b) the ventilator continuous positive airway pressure was not different compared with continuous flow systems; a nd c) continuous positive airway pressure with periodic hyperinflations red uced work of breathing (10.7 +/- 9.5 vs. 6.3 +/- 5.7 J/min, p < .05) and dy spnea sensation (1.6 +/- 1.2 vs. 1.1 +/- 0.8 cm, p < .05) increased end-exp iratory lung volume (1.6 +/- 0.8 vs. 2.0 +/- 0.9 L, p < .05) and Pao(2) (10 0 +/- 21 vs. 120 +/- 25 torr, p < .05) compared with ventilator continuous positive airway pressure. Conclusions: The continuous flow positive airway pressure systems tested ar e equally efficient; a ventilator can provide satisfactory continuous posit ive airway pressure; and the use of periodic hyperinflations during continu ous positive airway pressure can improve respiratory function and reduce th e work of breathing.