IN-VIVO ACTIVITY AND TOLERANCE OF CONVENTIONAL FORMULATION VERSUS FATEMULSION FORMULATION OF AMPHOTERICIN-B IN EXPERIMENTAL DISSEMINATED CANDIDIASIS IN NEUTROPENIC RABBITS

Amphotericin a can cause significant toxicity but this can be reduced by direct dilution into a fat emulsion (Intralipid). To investigate th e potential use of amphotericin B diluted in Intralipid, a study was m ade of its activity in the treatment of subacute disseminated candidia sis in persistently granulocytopenic rabbits, compared with the same d ose of amphotericin B diluted in dextrose. Amphotericin-B-fat emulsion was at least as effective as amphotericin-B-dextrose. Amphotericin-B- fat emulsion was significantly more effective than amphotericin-B-dext rose therapy in reducing candida colony counts in both kidney and live r tissues (P < 0.05). Furthermore, amphotericin-B-fat emulsion was fou nd less toxic on the renal function than conventional amphotericin B ( P < 0.05). From these experimental results, we conclude that amphoteri cin-B-fat emulsion (Intralipid) was at least as effective and less tox ic than conventional amphotericin B.