Miniaturization of enantioselective gas chromatography

In the context of the Titan Chiral Organics Explorer (TCOE) mission, the th eoretical and practical aspects of the miniaturization of enantioselective gas chromatography are discussed. The use of short columns (0.5 - 10 m) wit h a conventional inside diameter of 250 mum is proposed. The inside diamete r should be increased for vacuum-assisted GC-MS using a restrictor at the i nlet of the capillary. The feasibility of cryogenic enantioselective gas ch romatography is demonstrated. The hitherto elusive use of chiral mobile pha se additives in enantioselective gas chromatography is proposed.