Drug-induced torsade de pointes: the perspectives of industry

In 1996 the Committee for Proprietary Medicinal Products published their 'P oints to consider' which have been used as unofficial guidelines by drug co mpanies developing new pharmacologic compounds. Recommendaitons endorsed by the CPMP regarding hand measurement of the QT interval, QT dispersion, the Bazett QT interval correction for heart rate and the use of signal values for QTc changes compared to baseline are discussed in this paper. (Eur Hear t J Supplements 2001; 3 (Suppl K): K112-K113) (C) 2001 The European Society of Cardiology.