A novel palladium-catalyzed domino Tsuji-Trost-Heck process for the synthesis of tetrahydroanthracenes

Authors
Tietze, LF Nordmann, G
Citation
Lf. Tietze et G. Nordmann, A novel palladium-catalyzed domino Tsuji-Trost-Heck process for the synthesis of tetrahydroanthracenes, EUR J ORG C, (17), 2001, pp. 3247-3253
Citations number
29
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
1434193X → ACNP
Issue
17
Year of publication
2001
Pages
3247 - 3253
Database
ISI
SICI code
1434-193X(200109):17<3247:ANPDTP>2.0.ZU;2-K
Abstract
A novel type of palladium-catalyzed domino reaction is described combining Tsuji-Trost and Heck reactions. This method allows efficient access to tetr ahydroanthracene derivatives 1 in up to 89% isolated yield in a one-pot pro cess starting from the diketone 3. The tetrahydroanthracene structural moti f is found in many natural products, such as in the antibiotic tetracycline .