Lf. Tietze et G. Nordmann, A novel palladium-catalyzed domino Tsuji-Trost-Heck process for the synthesis of tetrahydroanthracenes, EUR J ORG C, (17), 2001, pp. 3247-3253
A novel type of palladium-catalyzed domino reaction is described combining
Tsuji-Trost and Heck reactions. This method allows efficient access to tetr
ahydroanthracene derivatives 1 in up to 89% isolated yield in a one-pot pro
cess starting from the diketone 3. The tetrahydroanthracene structural moti
f is found in many natural products, such as in the antibiotic tetracycline
.