A daughter of bradykinin that protects against septicaemia

Authors
Doggrell, SA
Citation
Sa. Doggrell, A daughter of bradykinin that protects against septicaemia, EXPERT OP I, 10(8), 2001, pp. 1567-1569
Citations number
8
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EXPERT OPINION ON INVESTIGATIONAL DRUGS
ISSN journal
13543784 → ACNP
Volume
10
Issue
8
Year of publication
2001
Pages
1567 - 1569
Database
ISI
SICI code
1354-3784(200108)10:8<1567:ADOBTP>2.0.ZU;2-7
Abstract
When the defence response of the body to infectious bacteria fails, septic shock ensues with hypotension and death. RPPGF, (1-5)-bradykinin, was until recently considered to be an inactive metabolite of bradykinin. in an anim al model of septicaemia (lipopolysaccharide administration to rats), RPPGF is protective, and can even prolong life. RPPGF, or stable mimetics, have p otential in the treatment of septic shock.