THERAPEUTIC EFFECTS OF OMOCONAZOLE NITRATE ON GUINEA-PIGS EXPERIMENTALLY INFECTED WITH TRICHOPHYTON-MENTAGROPHYTES

The therapeutic effects of topical omoconazole nitrate (OMZ) on Tricho phyton mentagrophytes-infected guinea-pigs were investigated. Once-dai ly topical application of 0.25, 0.5, 1 or 2% OMZ cream preparation for 14 consecutive days, starting on the fifth day after infection, was t herapeutically effective. The effectiveness appeared to increase with the concentration of the active preparation, and was nearly maximal at 1%. OMZ cream preparation (1% or 2%) was superior to 1% bifonazole cr eam preparation in improving local lesions and culture results. This r esult suggests that topical OMZ may be clinically useful in the treatm ent of patients with dermatophytosis and probably those with other sup erficial mycoses.