THE PHARMACOKINETICS OF ONCE-DAILY ORAL 400 MG OFLOXACIN IN PATIENTS WITH PERITONITIS COMPLICATING CONTINUOUS AMBULATORY PERITONEAL-DIALYSIS

Seven patients with end-stage renal disease requiring support by conti nuous ambulatory peritoneal dialysis received once-daily 400 mg oral o floxacin for 7 days for the treatment of bacterial peritonitis, Serum and peritoneal dialysis fluid (PDF) were collected for assay throughou t the course of the study and for 5 days thereafter, Ofloxacin, desmet hyl ofloxacin and ofloxacin-N-oxide accumulated over the course of the rapy and could still be detected in serum and PDF 5 days after the end of therapy, The mean elimination half-life of ofloxacin in serum was 32 +/- 7 h, desmethyl ofloxacin 45 +/- 26 h and for ofloxacin-N-oxide 44 +/- 15 h, The total mean recovery of ofloxacin and its metabolites from the PDF was 15.4%, This regimen results in serum and PDF concentr ations likely to be effective for the treatment of infection for at le ast 10 days.