IN-VITRO ANTIFUNGAL SUSCEPTIBILITY OF CLINICAL AND ENVIRONMENTAL FUSARIUM SPP STRAINS

The MICs of amphotericin B, miconazole, ketoconazole, flucytosine, itr aconazole and fluconazole for 19 isolates of Fusarium oxysporum, 16 Fu sarium solani, seven Fusarium verticilliodes, four Fusarium proliferat um, four Fusarium dimerum, three Fusarium equiseti, and one each of th e following species: Fusarium graminearum, Fusarium chlamydosporum, Fu sarium semitectum, Fusarium avenaceum and Fusarium subglutinans were d etermined by a broth microdilution method. Thirty-eight of these isola tes were of clinical origin and 20 from environmental sources. In gene ral, Fusarium spp. strains showed resistance to all the antifungals te sted. However, the most active agent was amphotericin B. Fluconazole a nd flucytosine were not active against any of the isolates tested. A c orrelation study of in-vitro testing with in-vivo outcome of amphoteri cin a of the cases of disseminated fusarium infections published is re ported.