ANTITUMOR EFFECTS OF LOCALIZED HYPERTHERMIA ON AN EXPERIMENTAL BONE-TUMOR USING AN INTRAMEDULLARY NAIL

A new localized hyperthermia system for an experimental bone tumour in the rabbit tibia was developed. This system was composed of an induct ion coil, generator and a Kirschner wire, which was inserted into the medullary canal of the tibia as a heat-generating ferromagnetic implan t. The metastatic bone tumour model was created by implantation of VX2 carcinoma in the medullary canal of the tibia diaphysis. Ten days aft er VX2 implantation, hyperthermia was induced for 50 min. Three weeks after the treatment, rabbits were sacrificed for histological and radi ological evaluation. According to the semi-quantitative scoring system , anti-tumour effects of the single dose of hyperthermia was noted rad iologically (p < 0.01) and histologically (p < 0.05) where the tempera ture was at a sufficient level to cause hyperthermia (> 42.5 degrees C ). This new heating method, which is relatively simple and clinically applicable, appears to be promising for the treatment of metastatic tu mours of the long bone.