M. Akagi et al., ANTITUMOR EFFECTS OF LOCALIZED HYPERTHERMIA ON AN EXPERIMENTAL BONE-TUMOR USING AN INTRAMEDULLARY NAIL, International journal of hyperthermia, 13(4), 1997, pp. 387-400
Citations number
19
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging",Oncology
A new localized hyperthermia system for an experimental bone tumour in
the rabbit tibia was developed. This system was composed of an induct
ion coil, generator and a Kirschner wire, which was inserted into the
medullary canal of the tibia as a heat-generating ferromagnetic implan
t. The metastatic bone tumour model was created by implantation of VX2
carcinoma in the medullary canal of the tibia diaphysis. Ten days aft
er VX2 implantation, hyperthermia was induced for 50 min. Three weeks
after the treatment, rabbits were sacrificed for histological and radi
ological evaluation. According to the semi-quantitative scoring system
, anti-tumour effects of the single dose of hyperthermia was noted rad
iologically (p < 0.01) and histologically (p < 0.05) where the tempera
ture was at a sufficient level to cause hyperthermia (> 42.5 degrees C
). This new heating method, which is relatively simple and clinically
applicable, appears to be promising for the treatment of metastatic tu
mours of the long bone.