IN-VITRO MODELING OF THE BACTERICIDAL ACTIVITY OF TEICOPLANIN VERSUS FLUCLOXACILLIN AS USED IN SURGICAL PROPHYLAXIS, AGAINST STAPHYLOCOCCUS-AUREUS

The bactericidal activities of teicoplanin and flucloxacillin in a 50: 50 mixture of human serum and Iso-sensitest broth were compared in an in-vitro pharmacokinetic model, at serum concentrations present during surgical prophylaxis. The bactericidal activity of teicoplanin with a nd without serum was also compared, Six strains of Staphylococcus aure us were tested, The bactericidal rate of teicoplanin in serum was sign ificantly lower than the rate in broth alone, However, there was no si gnificant difference in the bactericidal rates in serum of teicoplanin compared with flucloxacillin, an antibiotic which is commonly used as prophylaxis for certain surgical procedures.