CUTANEOUS METAPLASTIC SYNOVIAL CYST IN AN EHLERS-DANLOS PATIENT

Metaplastic synovial cyst is a recently recognized entity characterize d by a cystic space lined by polygonal cells and villous structures re sembling synovium pointing toward the lumen. It usually develops follo wing trauma. We report a 15-year-old girl with Ehlers-Danlos syndrome who developed a nodular lesion of her elbow without previous trauma. H istopathological and immunohistochemical studies yielded results simil ar to those reported in cases of cutaneous metaplastic synovial cyst. This case appears to be the first one reported of cutaneous metaplasti c synovial cyst associated with an Ehlers-Danlos syndrome. Cutaneous f ragility and anomalous scarring typical of Ehlers-Danlos syndrome may be related to the development of this pseudocyst. If so, other connect ive-tissue diseases with increased skin fragility could also be suscep tible to development of such lesions.