ETHYL 2-(ALPHA-HYDROXYHEXAFLUOROISOPROPYL)ACRYLATE AS A POTENTIAL PRECURSOR OF FLUORINE-CONTAINING AND SULFUR-CONTAINING CH-ACIDS

Authors
TEPLENICHEVA YL KOLOMIETS AF FOKIN AV
Citation
Yl. Teplenicheva et al., ETHYL 2-(ALPHA-HYDROXYHEXAFLUOROISOPROPYL)ACRYLATE AS A POTENTIAL PRECURSOR OF FLUORINE-CONTAINING AND SULFUR-CONTAINING CH-ACIDS, Russian chemical bulletin, 46(4), 1997, pp. 755-758
Citations number
3
Categorie Soggetti
Chemistry
Journal title
Russian chemical bulletin → ACNP
ISSN journal
10665285
Volume
46
Issue
4
Year of publication
1997
Pages
755 - 758
Database
ISI
SICI code
1066-5285(1997)46:4<755:E2AAPP>2.0.ZU;2-N
Abstract
The reactivity of ethyl 2-(alpha-hydroxyhexafluoroisopropyl)acrylate ( 1) was studied. The addition of thioacetic acid to compound 1 occurs a t 20 degrees C, while reactions with thiols proceed only at 120 degree s C and are accelerated in the presence of an acid catalyst. Dealkylat ion of acrylate 1 with iodotrimethyisilane affords ro-3-hydroxy-2-iodo methyl-3-trifluoromethylbutyric acid, which served as the starting com pound for the synthesis of 4-trifluoro-2-iodomethyl-3-trifluoromethylb utyroyl chloride, a potential precursor of alicyclic fluorine- and sul fur-containing CH-acids.