Value of structured clinical and scintigraphic protocols in acute pulmonary embolism

Purpose. To study the use of a combination of a clinical and scintigraphic protocol in relation to the final outcome diagnosis in patients with clinic al suspicion of acute pulmonary embolism (PE). Material and methods. A total of 170 patients with clinical suspicion of ac ute PE were all examined with ECG, blood chemistry, chest X-ray, pulmonary scintigraphy and selective pulmonary arteriograpy. The scintigraphic and cl inical probabilities of PE were estimated on visual analogue scales (VASs) by different readers unaware of each others' results. The follow-up time wa s 6 months. In order to establish the final diagnosis a final outcome commi ttee was created. They analysed in retrospect all the clinical and laborato ry data and established whether the patient had had PE or not. Results. The final outcome committee concluded that 53 patients had PE. Whe n the scintigraphic and clinical probability judgements were congruent, a c ombined probability of 1-25% (Le low probability) had a negative predictive value of 98%, When the combined probability was 26-75% (i.e. intermediate) half of the cases had PE. With a combined probability of 76-100%, (i.e. hi gh) the positive predictive value was 100'%. Conclusion. By applying a model of combined clinical and scintigraphic prob abilities for PE, the diagnosis is ruled in when the combined probability i s high, and ruled out when the combined probability is low. However, nearly half of the patients will still have art uncertain diagnosis for which fur ther diagnostic procedures may be allocated.