Analysis of the interactions of biologically active poly(methacrylic-aminosalicylic acid) supports with Ca2+ and Zn2+ by ultrafiltration

The interactions at pH 5.5 of the water-soluble poly(N-methacryloyl-4-amino salicylic acid) (poly(4-HMA)) with small amounts of Ca2+ and Zn2+, taking i nto consideration the statistical stereochemical distribution of the monome ric methacrylic units, are analysed by an ultrafiltration technique. The va lues of the interaction constants for the complexation of the salicylic sid e groups with each metal ion at these experimental conditions are given as a function of the ionic strength, and the results obtained indicate that Zn 2+ interacts with the polymer 16 times better than Ca2+. (C) 2001 Elsevier Science B.V. All rights reserved.