Lr. Rogers et al., Therapy-related myelodysplastic syndrome (t-MDS) in a patient with anaplastic astrocytoma: Successful treatment with allogeneic bone marrow transplant, J NEURO-ONC, 53(1), 2001, pp. 55-59
Objective and importance Therapy-related myelodysplastic syndrome (t-MDS) i
s a rare and typically fatal complication of therapy for cancer, including
brain tumors. We report successful therapy of t-MDS that developed after tr
eatment for an anaplastic astrocytoma.
Clinical presentation t-MDS developed four and one-half years after success
ful therapy (resection, radiation and chemotherapy) administered for a cere
bral anaplastic astrocytoma in a 34-year-old patient.
Intervention The patient was treated with allogeneic bone marrow transplant
(BMT) for t-MDS.
Conclusion She is alive three years after BMT with no evidence of brain tum
or and in complete remission from t-MDS. To our knowledge, this is the firs
t report of allogeneic BMT administered for t-MDS in an adult brain tumor p
atient. Clinicians must be alert to the development of t-MDS following chem
otherapy for brain tumors and initiate appropriate treatment promptly.