Therapy-related myelodysplastic syndrome (t-MDS) in a patient with anaplastic astrocytoma: Successful treatment with allogeneic bone marrow transplant

Citation
Lr. Rogers et al., Therapy-related myelodysplastic syndrome (t-MDS) in a patient with anaplastic astrocytoma: Successful treatment with allogeneic bone marrow transplant, J NEURO-ONC, 53(1), 2001, pp. 55-59
Citations number
18
Categorie Soggetti
Oncology
Journal title
JOURNAL OF NEURO-ONCOLOGY
ISSN journal
0167594X → ACNP
Volume
53
Issue
1
Year of publication
2001
Pages
55 - 59
Database
ISI
SICI code
0167-594X(2001)53:1<55:TMS(IA>2.0.ZU;2-N
Abstract
Objective and importance Therapy-related myelodysplastic syndrome (t-MDS) i s a rare and typically fatal complication of therapy for cancer, including brain tumors. We report successful therapy of t-MDS that developed after tr eatment for an anaplastic astrocytoma. Clinical presentation t-MDS developed four and one-half years after success ful therapy (resection, radiation and chemotherapy) administered for a cere bral anaplastic astrocytoma in a 34-year-old patient. Intervention The patient was treated with allogeneic bone marrow transplant (BMT) for t-MDS. Conclusion She is alive three years after BMT with no evidence of brain tum or and in complete remission from t-MDS. To our knowledge, this is the firs t report of allogeneic BMT administered for t-MDS in an adult brain tumor p atient. Clinicians must be alert to the development of t-MDS following chem otherapy for brain tumors and initiate appropriate treatment promptly.